Low LDL-cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s dementia and Parkinson’s disease: a Mendelian randomization study
نویسندگان
چکیده
1 Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; 2 The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; 3 The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Denmark; 4 Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark; and 5 Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
منابع مشابه
Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible for LDL cholesterol metabolism and biosynthesis(PCSK9 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), respectively) is associated with a high risk of Alzheimer's disease, vascular dementia, any dementia, and Parkinson's disease in the general population.Design ...
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